ARYMO ER is an opioid agonist indicated for the management of pain severe enough to require daily, around‑the‑clock, long‑term opioid treatment and for which alternative treatment options are inadequate.

ARYMO ER with Guardian™ Technology is an abuse-deterrent formulation (ADF) of extended-release morphine sulfate.

  • Available in 15, 30, and 60 mg dose strengths
  • Bioequivalent to MS Contin® (non-ADF)1
  • Can be taken with or without food2
  • Taken orally every 8 or 12 hours2
  • Does not contain a sequestered antagonist such as naltrexone
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Tablets are not actual size.

Abuse of ARYMO ER by injection, as well as by oral and nasal routes, is still possible.


A single dose of ARYMO ER greater than 60 mg, or a total daily dose greater than 120 mg, are only for use in patients in whom tolerance to an opioid of comparable potency has been established.

  • Use the lowest effective dosage for the shortest duration
  • ARYMO ER tablets should be taken whole, one tablet at a time, with enough water; should not be pre‑soaked, licked, or otherwise wet

Cutting, breaking, crushing, chewing, or dissolving ARYMO ER tablets will result in uncontrolled delivery of morphine that could lead to overdose and death.

For complete ARYMO ER dosage and administration instructions, refer to Section 2 of the Full Prescribing Information.